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Secretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants.
Kazi, Abdul Momin; Cortese, Margaret M; Yu, Ying; Lopman, Benjamin; Morrow, Ardythe L; Fleming, Jessica A; McNeal, Monica M; Steele, A Duncan; Parashar, Umesh D; Zaidi, Anita K M; Ali, Asad.
Affiliation
  • Kazi AM; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Cortese MM; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Yu Y; Perinatal Institute, Cincinnati Childrens' Hospital Medical Center, Ohio.
  • Lopman B; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Morrow AL; Perinatal Institute, Cincinnati Childrens' Hospital Medical Center, Ohio.
  • Fleming JA; Vaccine Access and Delivery, PATH, Seattle, Washington.
  • McNeal MM; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Ohio.
  • Steele AD; Vaccine Access and Delivery, PATH, Seattle, Washington.
  • Parashar UD; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Zaidi AKM; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
  • Ali A; Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
J Infect Dis ; 215(5): 786-789, 2017 Mar 01.
Article in En | MEDLINE | ID: mdl-28329092
ABSTRACT
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rotavirus Infections / ABO Blood-Group System / Rotavirus Vaccines Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Humans / Infant Country/Region as subject: Asia Language: En Journal: J Infect Dis Year: 2017 Type: Article Affiliation country: Pakistan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rotavirus Infections / ABO Blood-Group System / Rotavirus Vaccines Type of study: Clinical_trials / Prognostic_studies / Risk_factors_studies Limits: Humans / Infant Country/Region as subject: Asia Language: En Journal: J Infect Dis Year: 2017 Type: Article Affiliation country: Pakistan