Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year.

Lundkvist, Per; Pereira, Maria J; Katsogiannos, Petros; Sjöström, C David; Johnsson, Eva; Eriksson, Jan W

Lundkvist, Per; Pereira, Maria J; Katsogiannos, Petros; Sjöström, C David; Johnsson, Eva; Eriksson, Jan W.

Affiliation

Lundkvist P; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Pereira MJ; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Katsogiannos P; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Sjöström CD; AstraZeneca, Gothenburg, Sweden.
Johnsson E; AstraZeneca, Gothenburg, Sweden.
Eriksson JW; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Diabetes Obes Metab ; 19(9): 1276-1288, 2017 09.

Article in En | MEDLINE | ID: mdl-28345814

Subject(s)

Anti-Obesity Agents/therapeutic use; Benzhydryl Compounds/therapeutic use; Ghrelin/agonists; Glucosides/therapeutic use; Membrane Transport Modulators/therapeutic use; Obesity/drug therapy; Peptides/therapeutic use; Sodium-Glucose Transport Proteins/antagonists & inhibitors; Venoms/therapeutic use; Adiposity/drug effects; Anti-Obesity Agents/administration & dosage; Anti-Obesity Agents/adverse effects; Benzhydryl Compounds/administration & dosage; Benzhydryl Compounds/adverse effects; Body Mass Index; Cardiovascular Diseases/epidemiology; Cardiovascular Diseases/etiology; Cardiovascular Diseases/prevention & control; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination/adverse effects; Exenatide; Female; Follow-Up Studies; Ghrelin/metabolism; Glucosides/administration & dosage; Glucosides/adverse effects; Humans; Hypoglycemic Agents/administration & dosage; Hypoglycemic Agents/adverse effects; Hypoglycemic Agents/therapeutic use; Male; Membrane Transport Modulators/administration & dosage; Membrane Transport Modulators/adverse effects; Middle Aged; Obesity/metabolism; Obesity/physiopathology; Peptides/administration & dosage; Peptides/adverse effects; Prediabetic State/epidemiology; Prediabetic State/etiology; Prediabetic State/prevention & control; Proof of Concept Study; Risk Factors; Sodium-Glucose Transport Proteins/metabolism; Sweden/epidemiology; Venoms/administration & dosage; Venoms/adverse effects; Weight Loss/drug effects

Key words

dapagliflozin; exenatide; obesity; prediabetes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Venoms / Benzhydryl Compounds / Anti-Obesity Agents / Sodium-Glucose Transport Proteins / Membrane Transport Modulators / Ghrelin / Glucosides / Obesity Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Country/Region as subject: Europa Language: En Journal: Diabetes Obes Metab Journal subject: ENDOCRINOLOGIA / METABOLISMO Year: 2017 Type: Article Affiliation country: Sweden

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