Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer.

Sideras, Kostandinos; Biermann, Katharina; Yap, Kevin; Mancham, Shanta; Boor, Patrick P C; Hansen, Bettina E; Stoop, Hans J A; Peppelenbosch, Maikel P; van Eijck, Casper H; Sleijfer, Stefan; Kwekkeboom, Jaap; Bruno, Marco J

Sideras, Kostandinos; Biermann, Katharina; Yap, Kevin; Mancham, Shanta; Boor, Patrick P C; Hansen, Bettina E; Stoop, Hans J A; Peppelenbosch, Maikel P; van Eijck, Casper H; Sleijfer, Stefan; Kwekkeboom, Jaap; Bruno, Marco J.

Affiliation

Sideras K; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Biermann K; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Yap K; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Mancham S; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Boor PPC; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Hansen BE; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Stoop HJA; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
van Eijck CH; Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Sleijfer S; Department of Oncology, Erasmus MC-University Medical Center, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Kwekkeboom J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Bruno MJ; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

Int J Cancer ; 141(3): 572-582, 2017 08 01.

Article in En | MEDLINE | ID: mdl-28470686

Subject(s)

B7-H1 Antigen/metabolism; Common Bile Duct Neoplasms/mortality; Galanin/metabolism; HLA-G Antigens/metabolism; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism; Lymphocytes, Tumor-Infiltrating/immunology; Pancreatic Neoplasms/mortality; Receptors, Tumor Necrosis Factor, Member 14/metabolism; Adult; Aged; Aged, 80 and over; Ampulla of Vater/immunology; Ampulla of Vater/metabolism; Biomarkers, Tumor/metabolism; Common Bile Duct Neoplasms/immunology; Common Bile Duct Neoplasms/metabolism; Female; Humans; Lymphocytes, Tumor-Infiltrating/metabolism; Lymphocytes, Tumor-Infiltrating/pathology; Male; Middle Aged; Pancreatic Neoplasms/immunology; Pancreatic Neoplasms/metabolism; Prognosis; Retrospective Studies

Key words

HLA-G; HVEM; PD-L1; galectin-9; tumor infiltrating lymphocytes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Lymphocytes, Tumor-Infiltrating / Common Bile Duct Neoplasms / Galanin / Indoleamine-Pyrrole 2,3,-Dioxygenase / Receptors, Tumor Necrosis Factor, Member 14 / HLA-G Antigens / B7-H1 Antigen Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Int J Cancer Year: 2017 Type: Article Affiliation country: Netherlands

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