Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes.
Anticancer Res
; 37(5): 2633-2639, 2017 05.
Article
in En
| MEDLINE
| ID: mdl-28476838
ABSTRACT
BACKGROUND:
Taxanes are widely used to treat breast cancer patients. Taxanes are metabolized in human liver by the cytochrome CYP3A and are substrate of ATP-binding cassette multidrug transporters ABCB1. Single-nucleotide polymorphisms (SNPs) in genes involved in taxanes' metabolism could affect the inter-individual variability in reported toxicities. MATERIALS ANDMETHODS:
In this retrospective study, 152 women, affected by breast cancer and receiving a taxane-based chemotherapy, were enrolled. A peripheral blood sample was taken for genotyping the following polymorphisms CYP3A4* 1B (A>G), CYP3A5 *3 (G>A) and ABCB1 (C1236T; C3435T).RESULTS:
We observed an association between ABCB1 3435 T/T and lower grade of toxicities (p=0.05). No other association were found for CYP 3A4 *1B, 3A5*3 and ABCB1 C1236T.CONCLUSION:
ABCB1 3435 T/T seems to be associated to lower rate of toxicity in patients receiving taxanes. Further prospective and larger studies should be performed to clarify the role of this polymorphism.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Taxoids
/
Antineoplastic Agents
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Anticancer Res
Year:
2017
Type:
Article
Affiliation country:
Italy