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Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes.
Angelini, Silvia; Botticelli, Andrea; Onesti, Concetta Elisa; Giusti, Raffaele; Sini, Valentina; Durante, Valeria; Strigari, Lidia; Gentile, Giovanna; Cerbelli, Bruna; Pellegrini, Patrizia; Sgroi, Valentina; Occhipinti, Mario; DI Pietro, Francesca Romana; Rossi, Alessandro; Simmaco, Maurizio; Mazzuca, Federica; Marchetti, Paolo.
Affiliation
  • Angelini S; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Botticelli A; Department of Medical Oncology, Sant'Andrea Hospital, Rome, Italy.
  • Onesti CE; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Giusti R; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy elisaonesti@gmail.com.
  • Sini V; Department of Medical Oncology, Sant'Andrea Hospital, Rome, Italy.
  • Durante V; Department of Medical Oncology, Sant'Andrea Hospital, Rome, Italy.
  • Strigari L; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Gentile G; Santo Spirito Hospital, Lungotevere in Saxia, Rome, Italy.
  • Cerbelli B; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Pellegrini P; Department of Medical Oncology, Sant'Andrea Hospital, Rome, Italy.
  • Sgroi V; Laboratory of Medical Physics and Expert Systems, Regina Elena National Cancer Institute, Rome, Italy.
  • Occhipinti M; Dermopatic Institute of the Immacolata IDI-IRCSS, Rome, Italy.
  • DI Pietro FR; Department of Radiological Oncological and Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
  • Rossi A; Department of Medical Oncology, Sant'Andrea Hospital, Rome, Italy.
  • Simmaco M; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
  • Mazzuca F; Department of Medical Oncology, Sant'Andrea Hospital, Rome, Italy.
  • Marchetti P; Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.
Anticancer Res ; 37(5): 2633-2639, 2017 05.
Article in En | MEDLINE | ID: mdl-28476838
ABSTRACT

BACKGROUND:

Taxanes are widely used to treat breast cancer patients. Taxanes are metabolized in human liver by the cytochrome CYP3A and are substrate of ATP-binding cassette multidrug transporters ABCB1. Single-nucleotide polymorphisms (SNPs) in genes involved in taxanes' metabolism could affect the inter-individual variability in reported toxicities. MATERIALS AND

METHODS:

In this retrospective study, 152 women, affected by breast cancer and receiving a taxane-based chemotherapy, were enrolled. A peripheral blood sample was taken for genotyping the following polymorphisms CYP3A4* 1B (A>G), CYP3A5 *3 (G>A) and ABCB1 (C1236T; C3435T).

RESULTS:

We observed an association between ABCB1 3435 T/T and lower grade of toxicities (p=0.05). No other association were found for CYP 3A4 *1B, 3A5*3 and ABCB1 C1236T.

CONCLUSION:

ABCB1 3435 T/T seems to be associated to lower rate of toxicity in patients receiving taxanes. Further prospective and larger studies should be performed to clarify the role of this polymorphism.
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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Taxoids / Antineoplastic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Journal: Anticancer Res Year: 2017 Type: Article Affiliation country: Italy
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Taxoids / Antineoplastic Agents Type of study: Observational_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Journal: Anticancer Res Year: 2017 Type: Article Affiliation country: Italy