Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling.

Li, Jianshuang; Lu, Di; Liu, Huadie; Williams, Bart O; Overbeek, Paul A; Lee, Brendan; Zheng, Ling; Yang, Tao

Li, Jianshuang; Lu, Di; Liu, Huadie; Williams, Bart O; Overbeek, Paul A; Lee, Brendan; Zheng, Ling; Yang, Tao.

Affiliation

Li J; Hubei Key Laboratory of Cell Homeostasis, Department of Cell Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China.
Lu D; Program for Skeletal Disease and Tumor Metastasis, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Liu H; Program for Skeletal Disease and Tumor Metastasis, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Williams BO; Program for Skeletal Disease and Tumor Metastasis, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Overbeek PA; Program for Skeletal Disease and Tumor Metastasis, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Lee B; Department of Molecular and Cellular Biology.
Zheng L; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Yang T; Hubei Key Laboratory of Cell Homeostasis, Department of Cell Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P.R. China.

Hum Mol Genet ; 26(15): 2949-2960, 2017 08 01.

Article in En | MEDLINE | ID: mdl-28486600

Subject(s)

STAT3 Transcription Factor/metabolism; Sodium Channels/metabolism; Animals; Cilia/metabolism; Ciliopathies/genetics; Ciliopathies/metabolism; Cysts/metabolism; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases/metabolism; Humans; Kidney/metabolism; Kidney Diseases, Cystic/etiology; Kidney Diseases, Cystic/genetics; Kidney Diseases, Cystic/metabolism; MAP Kinase Signaling System; Mice; Mice, Transgenic; Models, Animal; Mutation; Phenotype; STAT3 Transcription Factor/genetics; Signal Transduction; Sodium Channels/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sodium Channels / STAT3 Transcription Factor Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2017 Type: Article

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