Systematic identification of functional residues of <i>Artemisia annua</i> amorpha-4,11-diene synthase.

Fang, Xin; Li, Jian-Xu; Huang, Jin-Quan; Xiao, You-Li; Zhang, Peng; Chen, Xiao-Ya

Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase.

Fang, Xin; Li, Jian-Xu; Huang, Jin-Quan; Xiao, You-Li; Zhang, Peng; Chen, Xiao-Ya.

Affiliation

Fang X; State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Li JX; State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Huang JQ; State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Xiao YL; State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Zhang P; State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Chen XY; State Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China xychen@sibs.ac.cn.

Biochem J ; 474(13): 2191-2202, 2017 06 16.

Article in En | MEDLINE | ID: mdl-28526743

Subject(s)

Alkyl and Aryl Transferases/metabolism; Artemisia annua/enzymology; Sesquiterpenes/metabolism; Alkyl and Aryl Transferases/chemistry; Alkyl and Aryl Transferases/genetics; Catalytic Domain; Models, Molecular; Mutagenesis, Site-Directed; Mutation/genetics; Polycyclic Sesquiterpenes; Protein Conformation; Sesquiterpenes/chemistry

Key words

artemisinin; catalytic efficiency; mechanism; product specificity; terpene synthase

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Alkyl and Aryl Transferases / Artemisia annua Type of study: Diagnostic_studies Language: En Journal: Biochem J Year: 2017 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google