A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating &#945;-Tubulin Expression.

Chang, Wen-Tsan; Liu, Wangta; Chiu, Yi-Han; Chen, Bing-Hung; Chuang, Shih-Chang; Chen, Yen-Chun; Hsu, Yun-Tzh; Lu, Mei-Jei; Chiou, Shean-Jaw; Chou, Chon-Kit; Chiu, Chien-Chih

A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression.

Chang, Wen-Tsan; Liu, Wangta; Chiu, Yi-Han; Chen, Bing-Hung; Chuang, Shih-Chang; Chen, Yen-Chun; Hsu, Yun-Tzh; Lu, Mei-Jei; Chiou, Shean-Jaw; Chou, Chon-Kit; Chiu, Chien-Chih.

Affiliation

Chang WT; Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. wtchang@kmu.edu.tw.
Liu W; Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. wtchang@kmu.edu.tw.
Chiu YH; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. liuwangta@kmu.edu.tw.
Chen BH; Department of Nursing, St. Mary's Junior College of Medicine, Nursing and Management, Yi-Lan 266, Taiwan. chiuyiham@smc.edu.tw.
Chuang SC; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. bhchen@kmu.edu.tw.
Chen YC; The Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. bhchen@kmu.edu.tw.
Hsu YT; Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. chuangsc@cc.kmu.edu.tw.
Lu MJ; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chuangsc@cc.kmu.edu.tw.
Chiou SJ; Transplantation Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. chuangsc@cc.kmu.edu.tw.
Chou CK; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. shiny_0224@yahoo.com.tw.
Chiu CC; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. 4a1h0007@stust.edu.tw.

Molecules ; 22(5)2017 May 21.

Article in En | MEDLINE | ID: mdl-28531143

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Autophagy/drug effects; Hepatocytes/drug effects; Phenyl Ethers/pharmacology; Tubulin/genetics; Animals; Antineoplastic Agents/chemical synthesis; BH3 Interacting Domain Death Agonist Protein/genetics; BH3 Interacting Domain Death Agonist Protein/metabolism; Beclin-1/genetics; Beclin-1/metabolism; Caspase 3/genetics; Caspase 3/metabolism; Cell Line; Cell Line, Tumor; DNA Damage; Epithelial Cells/cytology; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Extracellular Signal-Regulated MAP Kinases/genetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Gene Expression Regulation; Hepatocytes/metabolism; Hepatocytes/pathology; Histones/genetics; Histones/metabolism; Humans; Microtubule-Associated Proteins/genetics; Microtubule-Associated Proteins/metabolism; Organ Specificity; Phenyl Ethers/chemical synthesis; Rats; Sequestosome-1 Protein/genetics; Sequestosome-1 Protein/metabolism; Signal Transduction; Tubulin/metabolism; bcl-2-Associated X Protein/genetics; bcl-2-Associated X Protein/metabolism

Key words

4-phenoxyphenol; ERK; HCC; apoptosis; autophagy; microtubule; α-tubulin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenyl Ethers / Autophagy / Tubulin / Apoptosis / Hepatocytes / Antineoplastic Agents Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2017 Type: Article Affiliation country: Taiwan

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