Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Cell
; 169(6): 1119-1129.e11, 2017 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-28552347
ABSTRACT
The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Here, we mechanistically dissect the role of Tregs in HF and HFSC biology. Lineage-specific cell depletion revealed that Tregs promote HF regeneration by augmenting HFSC proliferation and differentiation. Transcriptional and phenotypic profiling of Tregs and HFSCs revealed that skin-resident Tregs preferentially express high levels of the Notch ligand family member, Jagged 1 (Jag1). Expression of Jag1 on Tregs facilitated HFSC function and efficient HF regeneration. Taken together, our work demonstrates that Tregs in skin play a major role in HF biology by promoting the function of HFSCs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stem Cells
/
T-Lymphocytes, Regulatory
/
Hair Follicle
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell
Year:
2017
Type:
Article
Affiliation country:
United kingdom