Comprehensive genomic profiling of different subtypes of nasopharyngeal carcinoma reveals similarities and differences to guide targeted therapy.

Ali, Siraj M; Yao, Ming; Yao, Jicheng; Wang, Jing; Cheng, Yuwei; Schrock, Alexa B; Chirn, Gung-Wei; Chen, Hui; Mu, Shuo; Gay, Laurie; Elvin, Julia A; Suh, James; Miller, Vincent A; Stephens, Philip J; Ross, Jeffrey S; Wang, Kai

Ali, Siraj M; Yao, Ming; Yao, Jicheng; Wang, Jing; Cheng, Yuwei; Schrock, Alexa B; Chirn, Gung-Wei; Chen, Hui; Mu, Shuo; Gay, Laurie; Elvin, Julia A; Suh, James; Miller, Vincent A; Stephens, Philip J; Ross, Jeffrey S; Wang, Kai.

Affiliation

Ali SM; Foundation Medicine, Inc, Cambridge, Massachusetts.
Yao M; OrigiMed, Shanghai, China.
Yao J; OrigiMed, Shanghai, China.
Wang J; OrigiMed, Shanghai, China.
Cheng Y; Yale University, New Haven, Connecticut.
Schrock AB; Foundation Medicine, Inc, Cambridge, Massachusetts.
Chirn GW; OrigiMed, Shanghai, China.
Chen H; OrigiMed, Shanghai, China.
Mu S; OrigiMed, Shanghai, China.
Gay L; Foundation Medicine, Inc, Cambridge, Massachusetts.
Elvin JA; Foundation Medicine, Inc, Cambridge, Massachusetts.
Suh J; Foundation Medicine, Inc, Cambridge, Massachusetts.
Miller VA; Foundation Medicine, Inc, Cambridge, Massachusetts.
Stephens PJ; Foundation Medicine, Inc, Cambridge, Massachusetts.
Ross JS; Foundation Medicine, Inc, Cambridge, Massachusetts.
Wang K; Albany Medical College, Albany, New York.

Cancer ; 123(18): 3628-3637, 2017 Sep 15.

Article in En | MEDLINE | ID: mdl-28581676

Subject(s)

Carcinoma, Squamous Cell/drug therapy; Carcinoma, Squamous Cell/genetics; Carcinoma/drug therapy; Carcinoma/genetics; Gene Expression Profiling/methods; Nasopharyngeal Neoplasms/drug therapy; Nasopharyngeal Neoplasms/genetics; Adenocarcinoma/drug therapy; Adenocarcinoma/genetics; Adenocarcinoma/mortality; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Carcinoma/mortality; Carcinoma, Squamous Cell/mortality; Class I Phosphatidylinositol 3-Kinases/genetics; Cohort Studies; Epstein-Barr Virus Infections/genetics; Epstein-Barr Virus Infections/pathology; Female; Gene Expression Regulation, Neoplastic; Genes, p16; Humans; Linear Models; Male; Middle Aged; Molecular Targeted Therapy/methods; Mutation; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms/mortality; Phosphatidylinositol 3-Kinases/genetics; Prognosis; Retrospective Studies; Survival Analysis

Key words

comprehensive genomic profiling; isocitrate dehydrogenase 2 (IDH2); nasopharyngeal carcinoma; targeted therapy; tumor mutation burden

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma / Carcinoma, Squamous Cell / Nasopharyngeal Neoplasms / Gene Expression Profiling Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Year: 2017 Type: Article

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