Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy.
Microvasc Res
; 114: 41-45, 2017 11.
Article
in En
| MEDLINE
| ID: mdl-28602918
ABSTRACT
BACKGROUND:
The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters.METHODS:
91 SSc patients were enrolled in this study. Serum VEGF and endostatin levels were determined. All patients underwent a renal Doppler ultrasoundRESULTS:
A significant positive correlation was observed between endostatin and renal Doppler parameters (p<0.0001). A negative correlation was observed between serum levels of endostatin and eGFR (p<0.01). In SSc patients with high resistive index, serum levels of endostatin were significantly (p<0.01) higher than in SSc patients with normal resistive index. The serum levels of endostatin significantly increased with progression of nailfold videocapillaroscopy damage (p<0.01) and were significantly (p<0.05) higher in SSc patients with digital ulcers than in SSc patients without digital ulcers.CONCLUSION:
This is the first study that assess in SSc patients intrarenal hemodynamic parameters and endostatin. In SSc patients, endostatin represents a marker of renal scleroderma-associated vasculopathy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Renal Circulation
/
Vascular Diseases
/
Scleroderma, Diffuse
/
Scleroderma, Limited
/
Endostatins
/
Vascular Endothelial Growth Factor A
/
Hemodynamics
/
Kidney
/
Kidney Diseases
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Microvasc Res
Year:
2017
Type:
Article