Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival.

Alderdice, Matthew; Dunne, Philip D; Cole, Aidan J; O'Reilly, Paul G; McArt, Darragh G; Bingham, Vicky; Fuchs, Marc-Aurel; McQuaid, Stephen; Loughrey, Maurice B; Murray, Graeme I; Samuel, Leslie M; Lawler, Mark; Wilson, Richard H; Salto-Tellez, Manuel; Coyle, Vicky M

Alderdice, Matthew; Dunne, Philip D; Cole, Aidan J; O'Reilly, Paul G; McArt, Darragh G; Bingham, Vicky; Fuchs, Marc-Aurel; McQuaid, Stephen; Loughrey, Maurice B; Murray, Graeme I; Samuel, Leslie M; Lawler, Mark; Wilson, Richard H; Salto-Tellez, Manuel; Coyle, Vicky M.

Affiliation

Alderdice M; Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Dunne PD; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Cole AJ; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
O'Reilly PG; Cancer Centre, Belfast Health and Social Care Trust, Belfast, Northern Ireland.
McArt DG; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Bingham V; Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Fuchs MA; Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
McQuaid S; Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Loughrey MB; Northern Ireland Molecular Pathology Laboratory, Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Murray GI; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Samuel LM; Department of Tissue Pathology, Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland.
Lawler M; Department of Pathology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
Wilson RH; Department of Clinical Oncology, Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK.
Salto-Tellez M; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.
Coyle VM; Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland.

Mod Pathol ; 30(9): 1287-1298, 2017 09.

Article in En | MEDLINE | ID: mdl-28621318

Subject(s)

Biomarkers, Tumor/genetics; Chemoradiotherapy, Adjuvant; Gene Expression Profiling/methods; Killer Cells, Natural/immunology; Lymphocytes, Tumor-Infiltrating/immunology; Neoadjuvant Therapy; Rectal Neoplasms/genetics; Rectal Neoplasms/therapy; Transcriptome; Biomarkers, Tumor/metabolism; Biopsy; CD56 Antigen/metabolism; Chemoradiotherapy, Adjuvant/adverse effects; Chemoradiotherapy, Adjuvant/mortality; Chi-Square Distribution; High-Throughput Nucleotide Sequencing; Humans; Kaplan-Meier Estimate; Killer Cells, Natural/metabolism; Lymphocytes, Tumor-Infiltrating/metabolism; Neoadjuvant Therapy/adverse effects; Neoadjuvant Therapy/mortality; Neoplasm Grading; Predictive Value of Tests; Proportional Hazards Models; Rectal Neoplasms/immunology; Rectal Neoplasms/mortality; Risk Factors; Time Factors; Treatment Outcome; Tumor Microenvironment

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rectal Neoplasms / Killer Cells, Natural / Biomarkers, Tumor / Lymphocytes, Tumor-Infiltrating / Neoadjuvant Therapy / Gene Expression Profiling / Chemoradiotherapy, Adjuvant / Transcriptome Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Mod Pathol Journal subject: PATOLOGIA Year: 2017 Type: Article

Fulltext

XML

PubMed Links

Search on Google