Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques.

Todorova, Biliana; Adam, Lucille; Culina, Slobodan; Boisgard, Raphaël; Martinon, Frédéric; Cosma, Antonio; Ustav, Mart; Kortulewski, Thierry; Le Grand, Roger; Chapon, Catherine

Todorova, Biliana; Adam, Lucille; Culina, Slobodan; Boisgard, Raphaël; Martinon, Frédéric; Cosma, Antonio; Ustav, Mart; Kortulewski, Thierry; Le Grand, Roger; Chapon, Catherine.

Affiliation

Todorova B; CEA - Université Paris Sud 11 - INSERM U1184, DRF/Jacob/Immunology of Viral infections and Autoimmune Diseases (IMVA), IDMIT infrastructure, 92265, Fontenay-aux-Roses, France.
Adam L; Vaccine research institute (VRI), Créteil, France.
Culina S; CEA - Université Paris Sud 11 - INSERM U1184, DRF/Jacob/Immunology of Viral infections and Autoimmune Diseases (IMVA), IDMIT infrastructure, 92265, Fontenay-aux-Roses, France.
Boisgard R; Vaccine research institute (VRI), Créteil, France.
Martinon F; CEA - Université Paris Sud 11 - INSERM U1184, DRF/Jacob/Immunology of Viral infections and Autoimmune Diseases (IMVA), IDMIT infrastructure, 92265, Fontenay-aux-Roses, France.
Cosma A; Vaccine research institute (VRI), Créteil, France.
Ustav M; CEA, Institute of Biomedical Imaging (I2BM), DSV/SHFJ/INSERM U1023, CEA, Orsay, France.
Kortulewski T; CEA - Université Paris Sud 11 - INSERM U1184, DRF/Jacob/Immunology of Viral infections and Autoimmune Diseases (IMVA), IDMIT infrastructure, 92265, Fontenay-aux-Roses, France.
Le Grand R; Vaccine research institute (VRI), Créteil, France.
Chapon C; CEA - Université Paris Sud 11 - INSERM U1184, DRF/Jacob/Immunology of Viral infections and Autoimmune Diseases (IMVA), IDMIT infrastructure, 92265, Fontenay-aux-Roses, France.

Sci Rep ; 7(1): 4122, 2017 06 23.

Article in En | MEDLINE | ID: mdl-28646234

Subject(s)

Adjuvants, Immunologic; Electroporation; Immunization; Plasmids/administration & dosage; Vaccines, DNA/administration & dosage; Vaccines, DNA/immunology; Animals; Antigen-Presenting Cells/immunology; Antigen-Presenting Cells/metabolism; Antigens/genetics; Antigens/immunology; Cytokines/metabolism; Epidermis/immunology; Epidermis/metabolism; Gene Expression; Immunization/methods; Inflammation/genetics; Inflammation/immunology; Inflammation/metabolism; Inflammation Mediators/metabolism; Injections, Intradermal; Keratinocytes/immunology; Keratinocytes/metabolism; Langerhans Cells/immunology; Langerhans Cells/metabolism; Macaca; Plasmids/genetics; Vaccination/methods; Vaccines, DNA/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Adjuvants, Immunologic / Immunization / Electroporation / Vaccines, DNA Limits: Animals Language: En Journal: Sci Rep Year: 2017 Type: Article Affiliation country: France

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