Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies.
Environ Health Perspect
; 125(6): 067006, 2017 06 14.
Article
in En
| MEDLINE
| ID: mdl-28657894
ABSTRACT
BACKGROUND:
Early-life arsenic exposure has been associated with reduced cell-mediated immunity, but little is known about its effects on humoral immunity.OBJECTIVE:
We evaluated whether prenatal and childhood arsenic exposure was associated with humoral immune function in school-aged children.METHODS:
Children born in a prospective motherchild cohort in rural Bangladesh were immunized with measles, mumps, and rubella (MMR) vaccines at 9 years of age (n=525). Arsenic exposure was assessed in urine (U-As), from mothers during pregnancy and their children at 4.5 and 9 years of age. Total IgG (tIgG), tIgE, tIgA, and MMR-specific IgG concentrations were measured in plasma using immunoassays.RESULTS:
Arsenic exposure was positively associated with child tIgG and tIgE, but not tIgA. The association with tIgG was mainly apparent in boys (p for interaction=0.055), in whom each doubling of maternal U-As was related to an increase in tIgG by 28 mg/dL. The associations of U-As at 9 years with tIgG and tIgE were evident in underweight children (p for interaction <0.032). Childhood arsenic exposure tended to impair mumps-specific vaccine response, although the evaluation was complicated by high preimmunization titers. Postimmunization mumpsspecific IgG titers tended to decrease with increasing U-As at 4.5 and 9 years of age [regression coefficient (ß)=−0.16; 95% confidence interval (CI) −0.33, 0.01; p=0.064 and ß=−0.12; 95% CI −0.27, −0.029; p=0.113, respectively) in 25% children with the lowest preexisting mumps-specific IgG titers.CONCLUSIONS:
Arsenic exposure increased tIgG and tIgE in plasma, and tended to decrease mumps-specific IgG in children at 9 years of age. https//doi.org/10.1289/EHP318.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arsenic
/
Environmental Exposure
/
Environmental Pollutants
Limits:
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Environ Health Perspect
Year:
2017
Type:
Article
Affiliation country:
Bangladesh