Cognitive function, treatment response to lithium, and social functioning in Japanese patients with bipolar disorder.
Bipolar Disord
; 19(7): 552-562, 2017 11.
Article
in En
| MEDLINE
| ID: mdl-28691278
ABSTRACT
OBJECTIVES:
Patients with bipolar disorder often suffer from cognitive impairment that significantly influences their functional outcome. However, it remains unknown whether lithium has a central role in cognition and functional outcome. We examined whether cognition and functional outcome were predicted by demographic and clinical variables, including the response to lithium, in lithium-treated patients with bipolar disorder.METHODS:
We evaluated 96 lithium-treated euthymic patients with bipolar disorder and 196 age- and-gender-matched healthy controls, using the Brief Assessment of Cognition in Schizophrenia (BACS). The patients were also assessed using the Social Functioning Scale (SFS) and "The Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder" (Alda) scale, which was evaluated as either a continuous measure of the total scale or a dichotomous criterion.RESULTS:
Multiple regression analysis revealed two keyfindings:
first, that the premorbid intelligence quotient, age, and number of mood episodes were predictors of the BACS composite score; and, second, that the BACS composite score, negative symptoms, and continuous measure on the total Alda scale (but not its dichotomy) predicted the total SFS score. Structural equation modeling (SEM) was used to confirm these findings, and additionally revealed that the Alda scale was significantly associated with negative symptoms and also the number of mood episodes, regardless of how it was evaluated.CONCLUSIONS:
SEM delineated how demographic and clinical variables, cognitive performance, and response to lithium treatment were causally associated with, and converged on, social function. The putative role of the Alda scale for social function warrants further study.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Social Adjustment
/
Bipolar Disorder
/
Cognition
/
Cognitive Dysfunction
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Bipolar Disord
Journal subject:
PSIQUIATRIA
Year:
2017
Type:
Article
Affiliation country:
Japan