Olea europaea Leaf Extract Improves the Efficacy of Temozolomide Therapy by Inducing MGMT Methylation and Reducing P53 Expression in Glioblastoma.

Tezcan, Gulcin; Tunca, Berrin; Demirci, Hilal; Bekar, Ahmet; Taskapilioglu, Mevlut Ozgur; Kocaeli, Hasan; Egeli, Unal; Cecener, Gulsah; Tolunay, Sahsine; Vatan, Ozgur

Tezcan, Gulcin; Tunca, Berrin; Demirci, Hilal; Bekar, Ahmet; Taskapilioglu, Mevlut Ozgur; Kocaeli, Hasan; Egeli, Unal; Cecener, Gulsah; Tolunay, Sahsine; Vatan, Ozgur.

Affiliation

Tezcan G; a Department of Medical Biology , Faculty of Medicine, Uludag University , Bursa , Turkey.
Tunca B; a Department of Medical Biology , Faculty of Medicine, Uludag University , Bursa , Turkey.
Demirci H; a Department of Medical Biology , Faculty of Medicine, Uludag University , Bursa , Turkey.
Bekar A; b Department of Neurosurgery , Faculty of Medicine, Uludag University , Bursa , Turkey.
Taskapilioglu MO; b Department of Neurosurgery , Faculty of Medicine, Uludag University , Bursa , Turkey.
Kocaeli H; b Department of Neurosurgery , Faculty of Medicine, Uludag University , Bursa , Turkey.
Egeli U; a Department of Medical Biology , Faculty of Medicine, Uludag University , Bursa , Turkey.
Cecener G; a Department of Medical Biology , Faculty of Medicine, Uludag University , Bursa , Turkey.
Tolunay S; c Department of Pathology , Faculty of Medicine, Uludag University , Bursa , Turkey.
Vatan O; d Department of Biology , Faculty of Arts and Sciences, Uludag University , Bursa , Turkey.

Nutr Cancer ; 69(6): 873-880, 2017.

Article in En | MEDLINE | ID: mdl-28718668

Subject(s)

DNA Methylation; DNA Modification Methylases/metabolism; DNA Repair Enzymes/metabolism; Dacarbazine/analogs & derivatives; Glioblastoma/drug therapy; Plant Extracts/pharmacology; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Proteins/metabolism; Aged; Cell Line, Tumor; Comet Assay; CpG Islands; DNA Damage; DNA Modification Methylases/genetics; DNA Repair Enzymes/genetics; Dacarbazine/therapeutic use; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm/genetics; Female; Humans; Inhibitory Concentration 50; Male; Middle Aged; Olea/chemistry; Plant Leaves/chemistry; Promoter Regions, Genetic; Temozolomide; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / DNA Modification Methylases / Tumor Suppressor Protein p53 / Glioblastoma / DNA Methylation / Tumor Suppressor Proteins / Dacarbazine / DNA Repair Enzymes Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Nutr Cancer Year: 2017 Type: Article Affiliation country: Turkey

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