TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.

Dewe, Joshua M; Fuller, Benjamin L; Lentini, Jenna M; Kellner, Stefanie M; Fu, Dragony

Dewe, Joshua M; Fuller, Benjamin L; Lentini, Jenna M; Kellner, Stefanie M; Fu, Dragony.

Affiliation

Dewe JM; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA.
Fuller BL; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA.
Lentini JM; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA.
Kellner SM; LMU Munich, Department of Chemistry, Munich, Germany.
Fu D; Department of Biology, Center for RNA Biology, University of Rochester, Rochester, New York, USA dragonyfu@rochester.edu.

Mol Cell Biol ; 37(21)2017 Nov 01.

Article in En | MEDLINE | ID: mdl-28784718

Subject(s)

Guanosine/analogs & derivatives; Intellectual Disability/genetics; RNA, Transfer/metabolism; tRNA Methyltransferases/genetics; tRNA Methyltransferases/metabolism; Catalysis; Cell Proliferation; Cell Survival; Guanosine/metabolism; HEK293 Cells; HeLa Cells; Homeostasis; Humans; Mutation; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species/metabolism

Key words

RNA; TRMT1; Trm1; dimethylguanosine; intellectual disability; methylation; methyltransferase; modification; neurodevelopment; tRNA modification

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: TRNA Methyltransferases / RNA, Transfer / Guanosine / Intellectual Disability Limits: Humans Language: En Journal: Mol Cell Biol Year: 2017 Type: Article Affiliation country: United States

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