ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.

Lownik, Joseph C; Luker, Andrea J; Damle, Sheela R; Cooley, Lauren Folgosa; El Sayed, Riham; Hutloff, Andreas; Pitzalis, Costantino; Martin, Rebecca K; El Shikh, Mohey Eldin M; Conrad, Daniel H

Lownik, Joseph C; Luker, Andrea J; Damle, Sheela R; Cooley, Lauren Folgosa; El Sayed, Riham; Hutloff, Andreas; Pitzalis, Costantino; Martin, Rebecca K; El Shikh, Mohey Eldin M; Conrad, Daniel H.

Affiliation

Lownik JC; Center for Clinical and Translational Research, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
Luker AJ; Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
Damle SR; Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
Cooley LF; Center for Clinical and Translational Research, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
El Sayed R; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
Hutloff A; Department of Clinical and Chemical Pathology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo 11562, Egypt; and.
Pitzalis C; German Rheumatism Research Centre Berlin, 10117 Berlin, Germany.
Martin RK; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
El Shikh MEM; Department of Microbiology and Immunology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298.
Conrad DH; Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

J Immunol ; 199(7): 2305-2315, 2017 10 01.

Article in En | MEDLINE | ID: mdl-28814605

Subject(s)

B-Lymphocytes/immunology; Gene Expression Regulation; Inducible T-Cell Co-Stimulator Ligand/metabolism; T-Lymphocytes, Helper-Inducer/immunology; T-Lymphocytes, Regulatory/immunology; ADAM10 Protein/deficiency; ADAM10 Protein/genetics; ADAM10 Protein/metabolism; Amyloid Precursor Protein Secretases/deficiency; Amyloid Precursor Protein Secretases/genetics; Amyloid Precursor Protein Secretases/metabolism; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental/immunology; Homeostasis; Humans; Inducible T-Cell Co-Stimulator Ligand/genetics; Inducible T-Cell Co-Stimulator Ligand/immunology; Membrane Proteins/deficiency; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Pyroglyphidae/immunology; Th1 Cells/immunology; Th17 Cells/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Gene Expression Regulation / T-Lymphocytes, Regulatory / T-Lymphocytes, Helper-Inducer / Inducible T-Cell Co-Stimulator Ligand Limits: Animals / Humans Language: En Journal: J Immunol Year: 2017 Type: Article

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