Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias.

Stanic, Jennifer; Mellone, Manuela; Napolitano, Francesco; Racca, Claudia; Zianni, Elisa; Minocci, Daiana; Ghiglieri, Veronica; Thiolat, Marie-Laure; Li, Qin; Longhi, Annalisa; De Rosa, Arianna; Picconi, Barbara; Bezard, Erwan; Calabresi, Paolo; Di Luca, Monica; Usiello, Alessandro; Gardoni, Fabrizio

Stanic, Jennifer; Mellone, Manuela; Napolitano, Francesco; Racca, Claudia; Zianni, Elisa; Minocci, Daiana; Ghiglieri, Veronica; Thiolat, Marie-Laure; Li, Qin; Longhi, Annalisa; De Rosa, Arianna; Picconi, Barbara; Bezard, Erwan; Calabresi, Paolo; Di Luca, Monica; Usiello, Alessandro; Gardoni, Fabrizio.

Affiliation

Stanic J; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy.
Mellone M; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania, Luigi Vanvitelli, Caserta, Italy.
Napolitano F; Ceinge Biotecnologie Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.
Racca C; Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Zianni E; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy.
Minocci D; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy.
Ghiglieri V; Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, 00143 Roma, Italy; Department of Philosophy, Human, Social and Educational Sciences, University of Perugia, Perugia, Italy.
Thiolat ML; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
Li Q; Motac Neuroscience Ltd, Manchester, United Kingdom; Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China.
Longhi A; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy.
De Rosa A; Ceinge Biotecnologie Avanzate, Naples, Italy.
Picconi B; Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, 00143 Roma, Italy.
Bezard E; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; Motac Neuroscience Ltd, Manchester, United Kingdom; Institute of Laboratory Animal Sciences, China Academy of Medical S
Calabresi P; Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, 00143 Roma, Italy; Clinica Neurologica, Università degli studi di Perugia, Ospedale Santa Maria della Misericordia, S. Andrea delle Fratte, 06156 Perugia, Italy.
Di Luca M; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy.
Usiello A; Ceinge Biotecnologie Avanzate, Naples, Italy; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania, Luigi Vanvitelli, Caserta, Italy.
Gardoni F; DiSFeB, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, 20133, Milano, Italy. Electronic address: fabrizio.gardoni@unimi.it.

Neurobiol Dis ; 108: 54-64, 2017 Dec.

Article in En | MEDLINE | ID: mdl-28823933

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Corpus Striatum/metabolism; Dyskinesia, Drug-Induced/metabolism; Levodopa/toxicity; Nerve Tissue Proteins/metabolism; Parkinsonian Disorders/metabolism; Post-Synaptic Density/metabolism; Vesicular Transport Proteins/metabolism; Adaptor Proteins, Signal Transducing/antagonists & inhibitors; Aged; Aged, 80 and over; Animals; Antiparkinson Agents/therapeutic use; Antiparkinson Agents/toxicity; Corpus Striatum/drug effects; Corpus Striatum/pathology; Dyskinesia, Drug-Induced/drug therapy; Dyskinesia, Drug-Induced/pathology; Female; Humans; Levodopa/therapeutic use; Macaca mulatta; Male; Nerve Tissue Proteins/antagonists & inhibitors; Oxidopamine; Parkinsonian Disorders/drug therapy; Parkinsonian Disorders/pathology; Post-Synaptic Density/drug effects; Post-Synaptic Density/pathology; Protein Binding/drug effects; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/metabolism; Synapses/drug effects; Synapses/metabolism; Tissue Culture Techniques; Vesicular Transport Proteins/antagonists & inhibitors; Rabphilin-3A

Key words

Cell-permeable peptides; Levodopa-induced dyskinesias; N-methyl-d-aspartate receptor; Pharmacological target

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Levodopa / Corpus Striatum / Parkinsonian Disorders / Vesicular Transport Proteins / Adaptor Proteins, Signal Transducing / Dyskinesia, Drug-Induced / Post-Synaptic Density / Nerve Tissue Proteins Limits: Aged / Aged80 / Animals / Female / Humans / Male Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2017 Type: Article Affiliation country: Italy

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