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Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile.
Barf, Tjeerd; Covey, Todd; Izumi, Raquel; van de Kar, Bas; Gulrajani, Michael; van Lith, Bart; van Hoek, Maaike; de Zwart, Edwin; Mittag, Diana; Demont, Dennis; Verkaik, Saskia; Krantz, Fanny; Pearson, Paul G; Ulrich, Roger; Kaptein, Allard.
Affiliation
  • Barf T; Acerta Pharma BV, Oss, The Netherlands t.barf@acerta-pharma.com.
  • Covey T; Acerta Pharma BV, Oss, The Netherlands.
  • Izumi R; Acerta Pharma BV, Oss, The Netherlands.
  • van de Kar B; Acerta Pharma BV, Oss, The Netherlands.
  • Gulrajani M; Acerta Pharma BV, Oss, The Netherlands.
  • van Lith B; Acerta Pharma BV, Oss, The Netherlands.
  • van Hoek M; Acerta Pharma BV, Oss, The Netherlands.
  • de Zwart E; Acerta Pharma BV, Oss, The Netherlands.
  • Mittag D; Acerta Pharma BV, Oss, The Netherlands.
  • Demont D; Acerta Pharma BV, Oss, The Netherlands.
  • Verkaik S; Acerta Pharma BV, Oss, The Netherlands.
  • Krantz F; Acerta Pharma BV, Oss, The Netherlands.
  • Pearson PG; Acerta Pharma BV, Oss, The Netherlands.
  • Ulrich R; Acerta Pharma BV, Oss, The Netherlands.
  • Kaptein A; Acerta Pharma BV, Oss, The Netherlands.
J Pharmacol Exp Ther ; 363(2): 240-252, 2017 11.
Article in En | MEDLINE | ID: mdl-28882879
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Benzamides / Protein-Tyrosine Kinases / Protein Kinase Inhibitors Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2017 Type: Article Affiliation country: Netherlands
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Benzamides / Protein-Tyrosine Kinases / Protein Kinase Inhibitors Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2017 Type: Article Affiliation country: Netherlands