Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL.

Kellici, Tahsin F; Chatziathanasiadou, Maria V; Lee, Min-Sung; Sayyad, Nisar; Geromichalou, Elena G; Vrettos, Eirinaios I; Tsiailanis, Antonis D; Chi, Seung-Wook; Geromichalos, George D; Mavromoustakos, Thomas; Tzakos, Andreas G

Kellici, Tahsin F; Chatziathanasiadou, Maria V; Lee, Min-Sung; Sayyad, Nisar; Geromichalou, Elena G; Vrettos, Eirinaios I; Tsiailanis, Antonis D; Chi, Seung-Wook; Geromichalos, George D; Mavromoustakos, Thomas; Tzakos, Andreas G.

Affiliation

Kellici TF; Department of Chemistry, University of Ioannina, Ioannina 45110, Greece. agtzakos@gmail.com.

Org Biomol Chem ; 15(37): 7956-7976, 2017 Sep 26.

Article in En | MEDLINE | ID: mdl-28902204

Subject(s)

Amino Acids/pharmacology; Antineoplastic Agents/pharmacology; Cytostatic Agents/pharmacology; Drug Design; Quercetin/pharmacology; bcl-X Protein/antagonists & inhibitors; Amino Acids/chemistry; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Cell Proliferation/drug effects; Cytostatic Agents/chemical synthesis; Cytostatic Agents/chemistry; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Quercetin/chemistry; Structure-Activity Relationship; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quercetin / Drug Design / Bcl-X Protein / Cytostatic Agents / Amino Acids / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Type: Article Affiliation country: Greece

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