Trimethylamine N-oxide (TMAO) is a counteracting solute of benzyl alcohol for multi-dose formulation of immunoglobulin.

Yoshizawa, Shunsuke; Oki, Shogo; Arakawa, Tsutomu; Shiraki, Kentaro

Yoshizawa, Shunsuke; Oki, Shogo; Arakawa, Tsutomu; Shiraki, Kentaro.

Affiliation

Yoshizawa S; Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan.
Oki S; Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan.
Arakawa T; Alliance Protein Laboratories, San Diego, CA 92121, United States.
Shiraki K; Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan. Electronic address: shiraki@bk.tsukuba.ac.jp.

Int J Biol Macromol ; 107(Pt A): 984-989, 2018 Feb.

Article in En | MEDLINE | ID: mdl-28939518

Subject(s)

Benzyl Alcohol/chemistry; Immunoglobulin G/chemistry; Methylamines/chemistry; Protein Aggregates/drug effects; Anti-Infective Agents/chemistry; Anti-Infective Agents/therapeutic use; Benzyl Alcohol/therapeutic use; Drug Compounding; Humans; Hydrogen Bonding/drug effects; Hydrophobic and Hydrophilic Interactions/drug effects; Immunoglobulin G/therapeutic use; Methylamines/therapeutic use; Molecular Dynamics Simulation; Protein Binding; Solutions/chemistry; Thermodynamics; Water/chemistry

Key words

Aggregation; Co-solvent; Immunoglobulin; Multi-dose formulation; TMAO

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Benzyl Alcohol / Protein Aggregates / Methylamines Limits: Humans Language: En Journal: Int J Biol Macromol Year: 2018 Type: Article Affiliation country: Japan

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