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Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway.
Kondo, K; Shaim, H; Thompson, P A; Burger, J A; Keating, M; Estrov, Z; Harris, D; Kim, E; Ferrajoli, A; Daher, M; Basar, R; Muftuoglu, M; Imahashi, N; Alsuliman, A; Sobieski, C; Gokdemir, E; Wierda, W; Jain, N; Liu, E; Shpall, E J; Rezvani, K.
Affiliation
  • Kondo K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shaim H; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Thompson PA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Burger JA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Keating M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Estrov Z; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Harris D; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Kim E; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ferrajoli A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Daher M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Basar R; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Muftuoglu M; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Imahashi N; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Alsuliman A; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Sobieski C; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Gokdemir E; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wierda W; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Jain N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Liu E; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shpall EJ; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Rezvani K; Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Leukemia ; 32(4): 960-970, 2018 04.
Article in En | MEDLINE | ID: mdl-28972595
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Leukemia, Lymphocytic, Chronic, B-Cell / STAT3 Transcription Factor / Tumor Microenvironment / B-Lymphocytes, Regulatory / B7-H1 Antigen / Programmed Cell Death 1 Receptor Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2018 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Leukemia, Lymphocytic, Chronic, B-Cell / STAT3 Transcription Factor / Tumor Microenvironment / B-Lymphocytes, Regulatory / B7-H1 Antigen / Programmed Cell Death 1 Receptor Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2018 Type: Article Affiliation country: United States