Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action.

Yu, Ziyang; He, Suqin; Wang, Dannie; Patel, Hitisha K; Miller, Chris P; Brown, Jeffrey L; Hattersley, Gary; Saeh, Jamal C

Yu, Ziyang; He, Suqin; Wang, Dannie; Patel, Hitisha K; Miller, Chris P; Brown, Jeffrey L; Hattersley, Gary; Saeh, Jamal C.

Affiliation

Yu Z; Radius Health, Inc., Waltham, Massachusetts. zyu@radiuspharm.com jsaeh@radiuspharm.com.
He S; Radius Health, Inc., Waltham, Massachusetts.
Wang D; Radius Health, Inc., Waltham, Massachusetts.
Patel HK; Radius Health, Inc., Waltham, Massachusetts.
Miller CP; Radius Health, Inc., Waltham, Massachusetts.
Brown JL; Radius Health, Inc., Waltham, Massachusetts.
Hattersley G; Radius Health, Inc., Waltham, Massachusetts.
Saeh JC; Radius Health, Inc., Waltham, Massachusetts. zyu@radiuspharm.com jsaeh@radiuspharm.com.

Clin Cancer Res ; 23(24): 7608-7620, 2017 Dec 15.

Article in En | MEDLINE | ID: mdl-28974548

Subject(s)

Androgens/pharmacology; Breast Neoplasms/drug therapy; Cell Proliferation/drug effects; Nitriles/pharmacology; Oxadiazoles/pharmacology; Receptors, Androgen/metabolism; Androgens/therapeutic use; Animals; Breast Neoplasms/genetics; Breast Neoplasms/pathology; Estrogen Receptor alpha/genetics; Estrogen Receptor alpha/metabolism; Estrogens; Female; Humans; MCF-7 Cells; Mice; Nitriles/therapeutic use; Oxadiazoles/therapeutic use; Receptors, Androgen/genetics; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxadiazoles / Breast Neoplasms / Receptors, Androgen / Cell Proliferation / Androgens / Nitriles Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2017 Type: Article

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