Deciphering molecular mechanisms of arginine deiminase-based therapy - Comparative response analysis in paired human primary and recurrent glioblastomas.

Maletzki, Claudia; Rosche, Yvonne; Riess, Christin; Scholz, Aline; William, Doreen; Classen, Carl Friedrich; Kreikemeyer, Bernd; Linnebacher, Michael; Fiedler, Tomas

Maletzki, Claudia; Rosche, Yvonne; Riess, Christin; Scholz, Aline; William, Doreen; Classen, Carl Friedrich; Kreikemeyer, Bernd; Linnebacher, Michael; Fiedler, Tomas.

Affiliation

Maletzki C; Molecular Oncology and Immunotherapy, Department of General Surgery, 18057 Rostock, Germany. Electronic address: claudia.maletzki@med.uni-rostock.de.
Rosche Y; Molecular Oncology and Immunotherapy, Department of General Surgery, 18057 Rostock, Germany; Institute for Medical Microbiology, Virology, and Hygiene, 18057 Rostock, Germany.
Riess C; Molecular Oncology and Immunotherapy, Department of General Surgery, 18057 Rostock, Germany; Institute for Medical Microbiology, Virology, and Hygiene, 18057 Rostock, Germany.
Scholz A; Molecular Oncology and Immunotherapy, Department of General Surgery, 18057 Rostock, Germany; Institute for Medical Microbiology, Virology, and Hygiene, 18057 Rostock, Germany.
William D; Molecular Oncology and Immunotherapy, Department of General Surgery, 18057 Rostock, Germany; University Childrens' Hospital, Rostock University Medical Centre, 18057 Rostock, Germany.
Classen CF; University Childrens' Hospital, Rostock University Medical Centre, 18057 Rostock, Germany.
Kreikemeyer B; Institute for Medical Microbiology, Virology, and Hygiene, 18057 Rostock, Germany.
Linnebacher M; Molecular Oncology and Immunotherapy, Department of General Surgery, 18057 Rostock, Germany.
Fiedler T; Institute for Medical Microbiology, Virology, and Hygiene, 18057 Rostock, Germany.

Chem Biol Interact ; 278: 179-188, 2017 Dec 25.

Article in En | MEDLINE | ID: mdl-28989041

Subject(s)

Autophagy/drug effects; Bacterial Proteins/toxicity; Cellular Senescence/drug effects; Hydrolases/toxicity; Autophagy/radiation effects; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cellular Senescence/radiation effects; Curcumin/toxicity; Gamma Rays; Glioblastoma/metabolism; Glioblastoma/pathology; Heat-Shock Proteins/metabolism; Humans; Hydrolases/genetics; Hydrolases/metabolism; Quinacrine/toxicity; Recombinant Proteins/biosynthesis; Recombinant Proteins/isolation & purification; Recombinant Proteins/toxicity; Resveratrol; Stilbenes/toxicity; Streptococcus pyogenes/enzymology; Superoxide Dismutase/metabolism; Up-Regulation/drug effects

Key words

Arginine-catabolizing enzymes; Cellular metabolism; Combination therapy; Patient-derived GBM cell lines; Radiation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Bacterial Proteins / Cellular Senescence / Hydrolases Limits: Humans Language: En Journal: Chem Biol Interact Year: 2017 Type: Article

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