Dietary creatine supplementation lowers hepatic triacylglycerol by increasing lipoprotein secretion in rats fed high-fat diet.

da Silva, Robin P; Leonard, Kelly-Ann; Jacobs, René L

da Silva, Robin P; Leonard, Kelly-Ann; Jacobs, René L.

Affiliation

da Silva RP; Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Leonard KA; Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
Jacobs RL; Group on the Molecular and Cell Biology of Lipids, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada. Electronic address: rjacobs@ualberta.ca.

J Nutr Biochem ; 50: 46-53, 2017 12.

Article in En | MEDLINE | ID: mdl-29031242

Subject(s)

Creatine/therapeutic use; Dietary Supplements; Lipoproteins/metabolism; Lipotropic Agents/therapeutic use; Liver/metabolism; Non-alcoholic Fatty Liver Disease/diet therapy; Triglycerides/metabolism; Animals; Biomarkers/blood; Biomarkers/metabolism; Cholesterol Esters/blood; Cholesterol Esters/metabolism; Creatine/adverse effects; Cytokines/blood; Cytokines/metabolism; Diet, High-Fat/adverse effects; Dietary Supplements/adverse effects; Enzyme Repression; Inflammation Mediators/blood; Inflammation Mediators/metabolism; Lipid Droplets/metabolism; Lipid Droplets/pathology; Lipoproteins/blood; Lipotropic Agents/adverse effects; Liver/immunology; Liver/pathology; Mitochondria, Liver/immunology; Mitochondria, Liver/metabolism; Mitochondria, Liver/pathology; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors; Mitochondrial Proton-Translocating ATPases/genetics; Mitochondrial Proton-Translocating ATPases/metabolism; Non-alcoholic Fatty Liver Disease/immunology; Non-alcoholic Fatty Liver Disease/metabolism; Non-alcoholic Fatty Liver Disease/pathology; Organ Size; Oxidation-Reduction; Random Allocation; Rats, Sprague-Dawley; Triglycerides/blood; Voltage-Dependent Anion Channels/antagonists & inhibitors; Voltage-Dependent Anion Channels/genetics; Voltage-Dependent Anion Channels/metabolism

Key words

Creatine; Lipid metabolism; Lipoprotein; Mitochondrial oxidation; NAFLD

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triglycerides / Dietary Supplements / Creatine / Non-alcoholic Fatty Liver Disease / Lipoproteins / Lipotropic Agents / Liver Language: En Journal: J Nutr Biochem Journal subject: BIOQUIMICA / CIENCIAS DA NUTRICAO Year: 2017 Type: Article Affiliation country: Canada

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