Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-ß peptide.

Dodacki, Agnès; Wortman, Matthew; Saubaméa, Bruno; Chasseigneaux, Stéphanie; Nicolic, Sophie; Prince, Nathalie; Lochus, Murielle; Raveu, Anne-Laure; Declèves, Xavier; Scherrmann, Jean-Michel; Patel, Shailendra B; Bourasset, Fanchon

Dodacki, Agnès; Wortman, Matthew; Saubaméa, Bruno; Chasseigneaux, Stéphanie; Nicolic, Sophie; Prince, Nathalie; Lochus, Murielle; Raveu, Anne-Laure; Declèves, Xavier; Scherrmann, Jean-Michel; Patel, Shailendra B; Bourasset, Fanchon.

Affiliation

Dodacki A; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.
Wortman M; Faculté de Pharmacie de Paris, Université Paris Descartes, UMR-S 1144, Paris, France.
Saubaméa B; Université Paris Diderot, UMR-S 1144, Paris, France.
Chasseigneaux S; Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, OH, USA.
Nicolic S; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.
Prince N; Faculté de Pharmacie de Paris, Université Paris Descartes, UMR-S 1144, Paris, France.
Lochus M; Université Paris Diderot, UMR-S 1144, Paris, France.
Raveu AL; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.
Declèves X; Faculté de Pharmacie de Paris, Université Paris Descartes, UMR-S 1144, Paris, France.
Scherrmann JM; Université Paris Diderot, UMR-S 1144, Paris, France.
Patel SB; Variabilité de Réponse aux Psychotropes, INSERM, U1144, Paris, France.
Bourasset F; Faculté de Pharmacie de Paris, Université Paris Descartes, UMR-S 1144, Paris, France.

Sci Rep ; 7(1): 13393, 2017 10 17.

Article in En | MEDLINE | ID: mdl-29042617

Subject(s)

ATP Binding Cassette Transporter, Subfamily G/genetics; ATP Binding Cassette Transporter, Subfamily G/metabolism; Amyloid beta-Peptides/metabolism; Blood-Brain Barrier/metabolism; Brain/metabolism; Gene Expression; ATP Binding Cassette Transporter, Subfamily G/chemistry; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Amyloid beta-Peptides/chemistry; Animals; Biomarkers; Capillary Permeability; Cell Membrane Permeability; Desmosterol/metabolism; Fluorescent Antibody Technique; Gene Targeting; Genetic Loci; Mice; Mice, Knockout; Models, Molecular; Protein Binding; Protein Conformation; Protein Multimerization; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Blood-Brain Barrier / Gene Expression / Amyloid beta-Peptides / ATP Binding Cassette Transporter, Subfamily G Limits: Animals Language: En Journal: Sci Rep Year: 2017 Type: Article Affiliation country: France

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