Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer.

Seligmann, Jenny F; Hatch, Ace J; Richman, Susan D; Elliott, Faye; Jacobs, Bart; Brown, Sarah; Hurwitz, Herbert; Barrett, Jennifer H; Quirke, Philip; Nixon, Andrew B; Seymour, Matthew T

Seligmann, Jenny F; Hatch, Ace J; Richman, Susan D; Elliott, Faye; Jacobs, Bart; Brown, Sarah; Hurwitz, Herbert; Barrett, Jennifer H; Quirke, Philip; Nixon, Andrew B; Seymour, Matthew T.

Affiliation

Seligmann JF; Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, England.
Hatch AJ; Duke University Medical Center, Durham, North Carolina.
Richman SD; Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, England.
Elliott F; Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, England.
Brown S; Clinical Trials Research Unit, University of Leeds, England.
Hurwitz H; Duke University Medical Center, Durham, North Carolina.
Barrett JH; Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, England.
Quirke P; Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, England.
Nixon AB; Duke University Medical Center, Durham, North Carolina.
Seymour MT; Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, England.

JAMA Oncol ; 4(4): 564-568, 2018 Apr 01.

Article in En | MEDLINE | ID: mdl-29075780

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Biomarkers, Pharmacological; Biomarkers, Tumor/genetics; Colorectal Neoplasms/drug therapy; Panitumumab/therapeutic use; Receptor, ErbB-3/genetics; Aged; Biomarkers, Pharmacological/analysis; Colorectal Neoplasms/genetics; Colorectal Neoplasms/mortality; Colorectal Neoplasms/pathology; Female; Gene Expression Regulation, Neoplastic/drug effects; Genetic Association Studies; Humans; Irinotecan/administration & dosage; Male; Middle Aged; Panitumumab/administration & dosage; Prognosis; RNA, Messenger/analysis; RNA, Messenger/genetics; Retrospective Studies; Survival Analysis; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Receptor, ErbB-3 / Biomarkers, Pharmacological / Panitumumab Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: JAMA Oncol Year: 2018 Type: Article Affiliation country: United kingdom

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