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A novel orally available small molecule that inhibits hepatitis B virus expression.
Mueller, Henrik; Wildum, Steffen; Luangsay, Souphalone; Walther, Johanna; Lopez, Anaïs; Tropberger, Philipp; Ottaviani, Giorgio; Lu, Wenzhe; Parrott, Neil John; Zhang, Jitao David; Schmucki, Roland; Racek, Tomas; Hoflack, Jean-Christophe; Kueng, Erich; Point, Floriane; Zhou, Xue; Steiner, Guido; Lütgehetmann, Marc; Rapp, Gianna; Volz, Tassilo; Dandri, Maura; Yang, Song; Young, John A T; Javanbakht, Hassan.
Affiliation
  • Mueller H; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Wildum S; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Luangsay S; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Walther J; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Lopez A; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Tropberger P; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Ottaviani G; Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China.
  • Lu W; Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China.
  • Parrott NJ; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Zhang JD; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Schmucki R; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Racek T; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Hoflack JC; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Kueng E; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Point F; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Zhou X; Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China.
  • Steiner G; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Lütgehetmann M; Department of Internal Medicine and Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Rapp G; Department of Internal Medicine and Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Volz T; Department of Internal Medicine and Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Dandri M; Department of Internal Medicine and Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Yang S; Roche Pharma Research and Early Development, Roche Innovation Center Shanghai, Shanghai 201203, China.
  • Young JAT; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland. Electronic address: john.young.jy3@roche.com.
  • Javanbakht H; Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland. Electronic address: ajbakht@gmail.com.
J Hepatol ; 68(3): 412-420, 2018 03.
Article in En | MEDLINE | ID: mdl-29079285
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Gene Expression Regulation, Viral / Hepatitis B virus / Hepatitis B, Chronic / Small Molecule Libraries Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2018 Type: Article Affiliation country: Switzerland
Fulltext
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XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Gene Expression Regulation, Viral / Hepatitis B virus / Hepatitis B, Chronic / Small Molecule Libraries Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Hepatol Journal subject: GASTROENTEROLOGIA Year: 2018 Type: Article Affiliation country: Switzerland