Autocrine Interleukin-10 Mediates Glucagon-Like Peptide-1 Receptor-Induced Spinal Microglial ß-Endorphin Expression.

Wu, Hai-Yun; Tang, Xue-Qi; Mao, Xiao-Fang; Wang, Yong-Xiang

Wu, Hai-Yun; Tang, Xue-Qi; Mao, Xiao-Fang; Wang, Yong-Xiang.

Affiliation

Wu HY; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Tang XQ; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Mao XF; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China.
Wang YX; King's Lab, Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, China yxwang@sjtu.edu.cn.

J Neurosci ; 37(48): 11701-11714, 2017 11 29.

Article in En | MEDLINE | ID: mdl-29084866

Subject(s)

Autocrine Communication/physiology; Glucagon-Like Peptide-1 Receptor/biosynthesis; Interleukin-10/biosynthesis; Microglia/metabolism; Spinal Cord/metabolism; beta-Endorphin/biosynthesis; Animals; Animals, Newborn; Autocrine Communication/drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Exenatide; Gene Expression; Glucagon-Like Peptide-1 Receptor/agonists; Glucagon-Like Peptide-1 Receptor/genetics; Interleukin-10/genetics; Interleukin-10/pharmacology; Male; Microglia/drug effects; Peptides/pharmacology; Rats; Rats, Wistar; Spinal Cord/cytology; Spinal Cord/drug effects; Venoms/pharmacology; beta-Endorphin/genetics

Key words

GLP-1 receptor; IL-10; autocrine; microglia; spinal cord; ß-endorphin

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Beta-Endorphin / Interleukin-10 / Microglia / Autocrine Communication / Glucagon-Like Peptide-1 Receptor Limits: Animals Language: En Journal: J Neurosci Year: 2017 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google