The limbic and neocortical contribution of α-synuclein, tau, and amyloid ß to disease duration in dementia with Lewy bodies.
Alzheimers Dement
; 14(3): 330-339, 2018 03.
Article
in En
| MEDLINE
| ID: mdl-29100980
ABSTRACT
INTRODUCTION:
We sought to assess the individual and combined contribution of limbic and neocortical α-synuclein, tau, and amyloid ß (Aß) to duration of illness in dementia with Lewy bodies (DLB).METHODS:
Quantitative digital pathology of limbic and neocortical α-synuclein, tau, and Aß was assessed in 49 patients with clinically probable DLB. Regression modeling examined the unique and shared contribution of each pathology to the variance of illness duration.RESULTS:
Patients with diffuse Lewy body disease had more severe pathology of each type and a shorter duration of illness than individuals with transitional Lewy body disease. The three pathologies accounted for 25% of the total variance of duration of illness, with 19% accounted for by α-synuclein alone or in combination with tau and Aß. When the diffuse Lewy body disease group was examined separately, α-synuclein deposition significantly exceeded that of tau and Aß. In this model, 20% of 24% total variance in the model for duration of illness was accounted for independently by α-synuclein.DISCUSSION:
In DLB, α-synuclein is an important predictor of disease duration, both independently and synergistically with tau and Aß.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amyloid beta-Peptides
/
Tau Proteins
/
Neocortex
/
Lewy Body Disease
/
Alpha-Synuclein
/
Limbic System
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Alzheimers Dement
Year:
2018
Type:
Article