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G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.
Simone, Roberto; Balendra, Rubika; Moens, Thomas G; Preza, Elisavet; Wilson, Katherine M; Heslegrave, Amanda; Woodling, Nathan S; Niccoli, Teresa; Gilbert-Jaramillo, Javier; Abdelkarim, Samir; Clayton, Emma L; Clarke, Mica; Konrad, Marie-Therese; Nicoll, Andrew J; Mitchell, Jamie S; Calvo, Andrea; Chio, Adriano; Houlden, Henry; Polke, James M; Ismail, Mohamed A; Stephens, Chad E; Vo, Tam; Farahat, Abdelbasset A; Wilson, W David; Boykin, David W; Zetterberg, Henrik; Partridge, Linda; Wray, Selina; Parkinson, Gary; Neidle, Stephen; Patani, Rickie; Fratta, Pietro; Isaacs, Adrian M.
Affiliation
  • Simone R; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Balendra R; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Moens TG; Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
  • Preza E; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Wilson KM; Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
  • Heslegrave A; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Woodling NS; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Niccoli T; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Gilbert-Jaramillo J; Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
  • Abdelkarim S; Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
  • Clayton EL; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Clarke M; MRC Centre for Neuromuscular Disease UCL Institute of Neurology, London, UK.
  • Konrad MT; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Nicoll AJ; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Mitchell JS; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Calvo A; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Chio A; MRC Prion Unit at UCL Institute of Prion Diseases, London, UK.
  • Houlden H; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
  • Polke JM; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre University of Turin, Turin, Italy.
  • Ismail MA; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre University of Turin, Turin, Italy.
  • Stephens CE; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Vo T; Neurogenetics Unit UCL Institute of Neurology, London, UK.
  • Farahat AA; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
  • Wilson WD; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
  • Boykin DW; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
  • Zetterberg H; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
  • Partridge L; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
  • Wray S; Department of Chemistry, Georgia State University, Atlanta, GA, USA.
  • Parkinson G; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
  • Neidle S; Clinical Neurochemistry Laboratory Institute of Neuroscience and Physiology Department of Psychiatry and Neurochemistry The Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden.
  • Patani R; UK Dementia Research Institute at UCL UCL Institute of Neurology, London, UK.
  • Fratta P; Department of Genetics, Evolution and Environment, Institute of Healthy Ageing, University College London, London, UK.
  • Isaacs AM; Max Planck Institute for Biology of Ageing, Cologne, Germany.
EMBO Mol Med ; 10(1): 22-31, 2018 01.
Article in En | MEDLINE | ID: mdl-29113975
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Small Molecule Libraries / G-Quadruplexes / Drug Discovery / Frontotemporal Dementia / C9orf72 Protein / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Small Molecule Libraries / G-Quadruplexes / Drug Discovery / Frontotemporal Dementia / C9orf72 Protein / Amyotrophic Lateral Sclerosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2018 Type: Article Affiliation country: United kingdom