Ribociclib Bioavailability Is Not Affected by Gastric pH Changes or Food Intake: In Silico and Clinical Evaluations.

Samant, Tanay S; Dhuria, Shyeilla; Lu, Yasong; Laisney, Marc; Yang, Shu; Grandeury, Arnaud; Mueller-Zsigmondy, Martin; Umehara, Kenichi; Huth, Felix; Miller, Michelle; Germa, Caroline; Elmeliegy, Mohamed

Samant, Tanay S; Dhuria, Shyeilla; Lu, Yasong; Laisney, Marc; Yang, Shu; Grandeury, Arnaud; Mueller-Zsigmondy, Martin; Umehara, Kenichi; Huth, Felix; Miller, Michelle; Germa, Caroline; Elmeliegy, Mohamed.

Affiliation

Samant TS; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Dhuria S; Achaogen, South San Francisco, California, USA.
Lu Y; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Laisney M; Novartis Pharma, Basel, Switzerland.
Yang S; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Grandeury A; Novartis Pharma, Basel, Switzerland.
Mueller-Zsigmondy M; Novartis Pharma, Basel, Switzerland.
Umehara K; Novartis Pharma, Basel, Switzerland.
Huth F; Novartis Pharma, Basel, Switzerland.
Miller M; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Germa C; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
Elmeliegy M; Novartis Pharmaceuticals, East Hanover, New Jersey, USA.

Clin Pharmacol Ther ; 104(2): 374-383, 2018 08.

Article in En | MEDLINE | ID: mdl-29134635

Subject(s)

Aminopyridines/pharmacokinetics; Antineoplastic Agents/pharmacokinetics; Computer Simulation; Food-Drug Interactions; Gastric Juice/chemistry; Models, Biological; Protein Kinase Inhibitors/pharmacokinetics; Purines/pharmacokinetics; Administration, Oral; Adolescent; Adult; Aminopyridines/administration & dosage; Aminopyridines/adverse effects; Aminopyridines/blood; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/adverse effects; Antineoplastic Agents/blood; Biological Availability; Cross-Over Studies; Drug Interactions; Fasting/blood; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Postprandial Period; Protein Kinase Inhibitors/administration & dosage; Protein Kinase Inhibitors/adverse effects; Protein Kinase Inhibitors/blood; Proton Pump Inhibitors/adverse effects; Purines/administration & dosage; Purines/adverse effects; Purines/blood; Solubility; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Computer Simulation / Food-Drug Interactions / Protein Kinase Inhibitors / Gastric Juice / Aminopyridines / Models, Biological / Antineoplastic Agents Type of study: Clinical_trials Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacol Ther Year: 2018 Type: Article Affiliation country: United States

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