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Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway.
Qin, Xiu-Ying; Wang, Ya-Nan; Yang, Xin-Ping; Liang, Juan-Juan; Liu, Ji-Lin; Luo, Zhao-Hui.
Affiliation
  • Qin XY; College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com and Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Guangxi Medical University, Nanning, 530021, China.
  • Wang YN; College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com.
  • Yang XP; College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com.
  • Liang JJ; College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com.
  • Liu JL; College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com.
  • Luo ZH; College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China. xyqin6688@163.com.
Dalton Trans ; 46(47): 16446-16454, 2017 Dec 21.
Article in En | MEDLINE | ID: mdl-29143014
ABSTRACT
The single crystals of two novel mixed-ligand copper(ii)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Copper / Vascular Endothelial Growth Factor Receptor-2 / Vascular Endothelial Growth Factor A / Coordination Complexes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2017 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Copper / Vascular Endothelial Growth Factor Receptor-2 / Vascular Endothelial Growth Factor A / Coordination Complexes Type of study: Prognostic_studies Limits: Humans Language: En Journal: Dalton Trans Journal subject: QUIMICA Year: 2017 Type: Article Affiliation country: China