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Structural rearrangements of the RNA polymerase III machinery during tRNA transcription initiation.
Ramsay, Ewan Phillip; Vannini, Alessandro.
Affiliation
  • Ramsay EP; The Institute of Cancer Research, London SW7 3RP, UK.
  • Vannini A; The Institute of Cancer Research, London SW7 3RP, UK. Electronic address: alessandro.vannini@icr.ac.uk.
Biochim Biophys Acta Gene Regul Mech ; 1861(4): 285-294, 2018 Apr.
Article in En | MEDLINE | ID: mdl-29155071
RNA polymerase III catalyses the synthesis of tRNAs in eukaryotic organisms. Through combined biochemical and structural characterisation, multiple auxiliary factors have been identified alongside RNA Polymerase III as critical in both facilitating and regulating transcription. Together, this machinery forms dynamic multi-protein complexes at tRNA genes which are required for polymerase recruitment, DNA opening and initiation and elongation of the tRNA transcripts. Central to the function of these complexes is their ability to undergo multiple conformational changes and rearrangements that regulate each step. Here, we discuss the available biochemical and structural data on the structural plasticity of multi-protein complexes involved in RNA Polymerase III transcriptional initiation and facilitated re-initiation during tRNA synthesis. Increasingly, structural information is becoming available for RNA polymerase III and its functional complexes, allowing for a deeper understanding of tRNA transcriptional initiation. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Polymerase III / RNA, Transfer / Transcription Initiation, Genetic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochim Biophys Acta Gene Regul Mech Year: 2018 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA Polymerase III / RNA, Transfer / Transcription Initiation, Genetic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochim Biophys Acta Gene Regul Mech Year: 2018 Type: Article