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New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.
Brethon, Anne; Chantalat, Laurent; Christin, Olivier; Clary, Laurence; Fournier, Jean-François; Gastreich, Marcus; Harris, Craig S; Isabet, Tatiana; Pascau, Jonathan; Thoreau, Etienne; Roche, Didier; Rodeschini, Vincent.
Affiliation
  • Brethon A; Edelris, 115 Avenue Lacassagne, 69003 Lyon, France.
  • Chantalat L; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Christin O; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Clary L; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Fournier JF; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Gastreich M; BioSolveIT GmbH, An der Ziegelei 79, 53757 Sankt Augustin, Germany.
  • Harris CS; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Isabet T; Synchrotron Soleil, L'Orme des Merisiers, Saint-Aubin - BP 48, 91192 Gif-sur-Yvette Cedex, France.
  • Pascau J; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Thoreau E; Galderma R&D, 2400 Route de Colles, 06410 Biot, France.
  • Roche D; Edelris, 115 Avenue Lacassagne, 69003 Lyon, France. Electronic address: didier.roche@edelris.com.
  • Rodeschini V; Edelris, 115 Avenue Lacassagne, 69003 Lyon, France. Electronic address: vincent.rodeschini@edelris.com.
Bioorg Med Chem Lett ; 27(24): 5373-5377, 2017 12 15.
Article in En | MEDLINE | ID: mdl-29157864
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 4-Butyrolactone / Caspase 1 / Dipeptides / Caspase Inhibitors Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Type: Article Affiliation country: France
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 4-Butyrolactone / Caspase 1 / Dipeptides / Caspase Inhibitors Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2017 Type: Article Affiliation country: France