Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.

Li, Minjing; Jin, Changzhu; Xu, Maolei; Zhou, Ling; Li, Defang; Yin, Yancun

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.

Li, Minjing; Jin, Changzhu; Xu, Maolei; Zhou, Ling; Li, Defang; Yin, Yancun.

Affiliation

Li M; Medicine and Pharmacy Research Center, Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China.
Jin C; Taishan Scholar Immunology Program, School of Basic Medical Sciences, Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China.
Xu M; The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China.
Zhou L; The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China.
Li D; Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China.
Yin Y; Taishan Scholar Immunology Program, School of Basic Medical Sciences, Binzhou Medical University, No. 346 Guanhai Road, Yantai City, Shandong Province, 264003, China. yinyc1985@126.com.

Cell Commun Signal ; 15(1): 52, 2017 Dec 16.

Article in En | MEDLINE | ID: mdl-29246230

Subject(s)

Adenylate Kinase/metabolism; Carcinoma, Hepatocellular/pathology; Hydroxymethyl and Formyl Transferases/metabolism; Liver Neoplasms/pathology; Multienzyme Complexes/metabolism; Nucleotide Deaminases/metabolism; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; TOR Serine-Threonine Kinases/metabolism; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Disease-Free Survival; Enzyme Activation; Gene Knockdown Techniques; Humans; Hydroxymethyl and Formyl Transferases/deficiency; Hydroxymethyl and Formyl Transferases/genetics; Molecular Targeted Therapy; Multienzyme Complexes/deficiency; Multienzyme Complexes/genetics; Nucleotide Deaminases/deficiency; Nucleotide Deaminases/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Up-Regulation

Key words

AMPK; ATIC; Hepatocellular carcinoma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenylate Kinase / Carcinoma, Hepatocellular / Hydroxymethyl and Formyl Transferases / Ribosomal Protein S6 Kinases, 70-kDa / TOR Serine-Threonine Kinases / Liver Neoplasms / Multienzyme Complexes / Nucleotide Deaminases Limits: Humans Language: En Journal: Cell Commun Signal Year: 2017 Type: Article Affiliation country: China

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