Chronic disseminated candidiasis and acute leukemia: Impact on survival and hematopoietic stem cell transplantation agenda.
Med Mal Infect
; 48(3): 202-206, 2018 May.
Article
in En
| MEDLINE
| ID: mdl-29307444
ABSTRACT
OBJECTIVES:
To study the management of chronic disseminated candidiasis (CDC) in patients presenting with acute leukemia. PATIENTS ANDMETHODS:
Single-center retrospective study of acute leukemia patients (2006-2015) to investigate three aspects of CDC its impact on the time interval between diagnosis and hematopoietic stem cell transplantation, when required (non-parametric Wilcoxon-Mann-Whitney test); its impact on overall survival (Cox proportional hazard regression model); antifungal therapeutic strategies implemented.RESULTS:
A total of 639 patients presenting with acute leukemia were included; 144 were transplanted and 29 developed CDC. CDC did not significantly increase the time interval between diagnosis and transplantation, nor did it impact the overall survival of recipients. An improved overall survival was observed in non-transplanted acute leukemia patients presenting with CDC.CONCLUSION:
CDC should not postpone transplantation if antifungal treatment is optimized.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Opportunistic Infections
/
Candidiasis
/
Leukemia
/
Hematopoietic Stem Cell Transplantation
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Med Mal Infect
Year:
2018
Type:
Article
Affiliation country:
France