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Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome in Adults.
Esnault, Pierre; Hraiech, Sami; Bordes, Julien; Forel, Jean-Marie; Adda, Mélanie; Rambaud, Romain; Lehingue, Samuel; Roch, Antoine; Papazian, Laurent; Guervilly, Christophe.
Affiliation
  • Esnault P; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Hraiech S; Intensive Care Unit, Sainte Anne Military Hospital, Toulon, France.
  • Bordes J; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Forel JM; Intensive Care Unit, Sainte Anne Military Hospital, Toulon, France.
  • Adda M; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Rambaud R; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Lehingue S; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Roch A; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Papazian L; From the Medical Intensive Care Unit, Respiratory Distress and Severe Infections, Nord Hospital, URMITE CNRS-UMR 6236, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
  • Guervilly C; Department of Emergency, Nord Hospital, Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Marseille, France.
Anesth Analg ; 129(2): e48-e51, 2019 08.
Article in En | MEDLINE | ID: mdl-29337729
ABSTRACT
This single-center case series investigated the effect of almitrine infusion on PaO2/fraction of inspired oxygen (FIO2) in 25 patients on veno-venous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. A positive trial was defined as an increase of PaO2/FIO2 ratio ≥20%. Thirty-two trials were performed. Twenty (62.5%, 95% confidence interval, 37.5%-75%) trials in 18 patients were positive, with a median PaO2/FIO2 ratio increase of 35% (25%-43%). A focal acute respiratory distress syndrome and inhaled nitric oxide therapy were more frequent in patients with a positive response to almitrine. We observed no complications of almitrine use.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiration / Respiratory Distress Syndrome / Extracorporeal Membrane Oxygenation / Almitrine / Respiratory System Agents Type of study: Diagnostic_studies / Observational_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Anesth Analg Year: 2019 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiration / Respiratory Distress Syndrome / Extracorporeal Membrane Oxygenation / Almitrine / Respiratory System Agents Type of study: Diagnostic_studies / Observational_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Anesth Analg Year: 2019 Type: Article Affiliation country: France