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Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates.
Weiß, Frederik; Hammer, Helen S; Klein, Kathrin; Planatscher, Hannes; Zanger, Ulrich M; Norén, Agneta; Wegler, Christine; Artursson, Per; Joos, Thomas O; Poetz, Oliver.
Affiliation
  • Weiß F; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Hammer HS; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Klein K; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Planatscher H; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Zanger UM; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Norén A; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Wegler C; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Artursson P; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Joos TO; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
  • Poetz O; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); SIGNATOPE GmbH, Reutlingen, Germany (F.W., H.S.H., H.P., T.O.J., O.P.); Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (K.K., U.M.Z.);
Drug Metab Dispos ; 46(4): 387-396, 2018 04.
Article in En | MEDLINE | ID: mdl-29343608
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Mass Spectrometry / Biological Transport / Immunoassay / Cytochrome P-450 Enzyme System Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2018 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Mass Spectrometry / Biological Transport / Immunoassay / Cytochrome P-450 Enzyme System Limits: Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2018 Type: Article