Diagnostic value of stress thallium-201/rest technetium-99m-sestamibi sequential dual isotope high-speed myocardial perfusion imaging for the detection of haemodynamically relevant coronary artery stenosis.
J Nucl Cardiol
; 26(4): 1269-1279, 2019 08.
Article
in En
| MEDLINE
| ID: mdl-29380286
ABSTRACT
BACKGROUND:
The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR).METHODS:
Fifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of ≥ 90% stenosis/occlusion or fractional flow reserve ≤ 0.80 for coronary stenosis ≥ 50%.RESULTS:
FFR was measured in 69 of 162 coronary vessels, with 1.28 ± 0.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory.CONCLUSIONS:
DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thallium Radioisotopes
/
Technetium Tc 99m Sestamibi
/
Radiopharmaceuticals
/
Coronary Stenosis
/
Myocardial Perfusion Imaging
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Nucl Cardiol
Journal subject:
CARDIOLOGIA
Year:
2019
Type:
Article
Affiliation country:
France