B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells.

Luo, Wei; Weisel, Florian; Shlomchik, Mark J

Luo, Wei; Weisel, Florian; Shlomchik, Mark J.

Affiliation

Luo W; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Weisel F; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Shlomchik MJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. Electronic address: mshlomch@pitt.edu.

Immunity ; 48(2): 313-326.e5, 2018 02 20.

Article in En | MEDLINE | ID: mdl-29396161

Subject(s)

CD40 Antigens/physiology; Germinal Center/immunology; Proto-Oncogene Proteins c-myc/biosynthesis; Receptors, Antigen, B-Cell/physiology; Signal Transduction/physiology; Animals; Forkhead Box Protein O1/physiology; MAP Kinase Signaling System/physiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B/physiology; Phosphatidylinositol 3-Kinases/physiology; Proto-Oncogene Proteins c-akt/physiology; Syk Kinase/physiology

Key words

Akt; B cell; B cell receptor; CD40; Foxo1; Myc; Syk; affinity maturation; germinal center

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, B-Cell / Signal Transduction / Proto-Oncogene Proteins c-myc / Germinal Center / CD40 Antigens Limits: Animals Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2018 Type: Article Affiliation country: United States

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