High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor-/CD52- T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation.

Loeff, Floris C; Falkenburg, J H Frederik; Hageman, Lois; Huisman, Wesley; Veld, Sabrina A J; van Egmond, H M Esther; van de Meent, Marian; von dem Borne, Peter A; Veelken, Hendrik; Halkes, Constantijn J M; Jedema, Inge

High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor^-/CD52^- T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell-Depleted Allogeneic Stem Cell Transplantation.

Loeff, Floris C; Falkenburg, J H Frederik; Hageman, Lois; Huisman, Wesley; Veld, Sabrina A J; van Egmond, H M Esther; van de Meent, Marian; von dem Borne, Peter A; Veelken, Hendrik; Halkes, Constantijn J M; Jedema, Inge.

Affiliation

Loeff FC; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and f.c.loeff@lumc.nl.
Falkenburg JHF; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
Hageman L; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
Huisman W; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
Veld SAJ; Department of Hematopoiesis, Sanquin Research, 1066CX Amsterdam, the Netherlands.
van Egmond HME; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
van de Meent M; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
von dem Borne PA; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
Veelken H; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
Halkes CJM; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.
Jedema I; Department of Hematology, Leiden University Medical Center, 2333ZA Leiden, the Netherlands; and.

J Immunol ; 200(6): 2199-2208, 2018 03 15.

Article in En | MEDLINE | ID: mdl-29427418

Subject(s)

Alemtuzumab/pharmacology; CD52 Antigen/genetics; Membrane Glycoproteins/genetics; Membrane Proteins/genetics; Mutation/genetics; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; Adult; B-Lymphocytes/immunology; Graft vs Host Disease/genetics; Graft vs Host Disease/immunology; Hematopoietic Stem Cell Transplantation/methods; Humans; Killer Cells, Natural/immunology; Lymphocyte Depletion/methods; Mutation Rate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / T-Lymphocytes / Alemtuzumab / CD52 Antigen / Membrane Proteins / Mutation Limits: Adult / Humans Language: En Journal: J Immunol Year: 2018 Type: Article

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