Serum uric acid is associated with incidence of heart failure with preserved ejection fraction and cardiovascular events in patients with arterial hypertension.
J Clin Hypertens (Greenwich)
; 20(3): 560-567, 2018 03.
Article
in En
| MEDLINE
| ID: mdl-29447438
ABSTRACT
The objective of the present study was to evaluate clinical implications of serum uric acid (UA) on the progression of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients. A total of 1009 adult patients with left ventricular hypertrophy and suspected left ventricular diastolic dysfunction were enrolled at our hospital from January 2008 to December 2011. With a median follow-up of 7.2 years, 136 (13.2%) patients developed new-onset HFpEF and 151 (15.0%) had major adverse cardiovascular events (MACEs). Compared with the lowest UA tertile of UA (<302 µmol L-1 ), subjects in the highest tertile (>367 µmol L-1 ) had a higher risk of developing new-onset HFpEF (HR 1.761, 95% CI 1.119-2.772, P = .015) as well as MACEs (HR 1.664, 95% CI 1.086-2.547, P = .019). Our findings indicate that hyperuricemia is associated with detrimental effects in terms of the incidence of new-onset HFpEF as well as MACEs in hypertensive patient.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uric Acid
/
Hyperuricemia
/
Heart Failure
/
Hypertension
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Clin Hypertens (Greenwich)
Journal subject:
ANGIOLOGIA
Year:
2018
Type:
Article
Affiliation country:
China