[Changes in spatial relationships between catecholamine- and nitroxidergic neurons in the nuclei of the caudal brain stem in the development of hypertension]. / Izmenenie prostranstvennykh vzaimootnoshenii katekholamin- i nitroksidergicheskikh neironov v iadrakh kaudal'noi chasti stvola mozga pri razvitii arterial'noi gipertenzii.
Zh Nevrol Psikhiatr Im S S Korsakova
; 118(1): 61-66, 2018.
Article
in Ru
| MEDLINE
| ID: mdl-29460906
ABSTRACT
AIM:
To obtain the data on the spatial relationships between catecholamine (TH-positive) and nitroxidergic (nNOS-positive) neurons in vasomotor nuclei of the medulla in different periods of hypertension development. MATERIAL ANDMETHODS:
The experiment was performed on male Wistar rats (n=45) with induced renovascular hypertension (RVH). TH and nNOS in neurons of solitary tract nuclei, reticular small-and giant cell nuclei were detected using immunohistochemical methods. RESULTS ANDCONCLUSION:
The most early and severe changes in the intensity of reaction and amount of nNOS-positive neurons were noted in the solitary tract nucleus. Significant changes in the quantitative parameters of TH-positive neurons in RVH were identified only in the reticular giant cell nucleus but they appeared later and were less expressed compared to nNOS-positive cells. This resulted in the changes of spatial relationships between two types of neurons and remodeling of the bulbar region of the cardiovascular center.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Stem
/
Nitrergic Neurons
/
Hypertension
Limits:
Animals
Language:
Ru
Journal:
Zh Nevrol Psikhiatr Im S S Korsakova
Journal subject:
NEUROLOGIA
/
PSIQUIATRIA
Year:
2018
Type:
Article