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Tau protein liquid-liquid phase separation can initiate tau aggregation.
Wegmann, Susanne; Eftekharzadeh, Bahareh; Tepper, Katharina; Zoltowska, Katarzyna M; Bennett, Rachel E; Dujardin, Simon; Laskowski, Pawel R; MacKenzie, Danny; Kamath, Tarun; Commins, Caitlin; Vanderburg, Charles; Roe, Allyson D; Fan, Zhanyun; Molliex, Amandine M; Hernandez-Vega, Amayra; Muller, Daniel; Hyman, Anthony A; Mandelkow, Eckhard; Taylor, J Paul; Hyman, Bradley T.
Affiliation
  • Wegmann S; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA swegmann@mgh.harvard.edu bhyman@mgh.harvard.edu.
  • Eftekharzadeh B; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Tepper K; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Zoltowska KM; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Bennett RE; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Dujardin S; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Laskowski PR; Department for Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
  • MacKenzie D; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Kamath T; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Commins C; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Vanderburg C; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Roe AD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Fan Z; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
  • Molliex AM; Department of Cell & Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Hernandez-Vega A; Max-Planck Institute for Molecular Cell Biology & Genetics, Dresden, Germany.
  • Muller D; Department for Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
  • Hyman AA; Department for Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
  • Mandelkow E; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  • Taylor JP; Max-Planck Institute for Metabolism Research, Hamburg Outstation c/o DESY, Hamburg, Germany.
  • Hyman BT; CAESAR Research Center, Bonn, Germany.
EMBO J ; 37(7)2018 04 03.
Article in En | MEDLINE | ID: mdl-29472250
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Tau Proteins / Alzheimer Disease / Protein Aggregation, Pathological / Amyotrophic Lateral Sclerosis / Neurons Limits: Aged80 / Animals / Female / Humans Language: En Journal: EMBO J Year: 2018 Type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Tau Proteins / Alzheimer Disease / Protein Aggregation, Pathological / Amyotrophic Lateral Sclerosis / Neurons Limits: Aged80 / Animals / Female / Humans Language: En Journal: EMBO J Year: 2018 Type: Article