Inhibition of Collagen Related Peptide Induced Platelet Activation and Apoptosis by Ceritinib.

Cao, Hang; Umbach, Anja T; Bissinger, Rosi; Gawaz, Meinrad; Lang, Florian

Cao, Hang; Umbach, Anja T; Bissinger, Rosi; Gawaz, Meinrad; Lang, Florian.

Affiliation

Cao H; Department of Internal Medicine III, Tübingen, Germany.
Umbach AT; Department of Internal Medicine III, Tübingen, Germany.
Bissinger R; Department of Internal Medicine III, Tübingen, Germany.
Gawaz M; Department of Internal Medicine III, Tübingen, Germany.
Lang F; Department of Physiology, Eberhard-Karls-University, Tübingen, Germany.

Cell Physiol Biochem ; 45(4): 1707-1716, 2018.

Article in En | MEDLINE | ID: mdl-29490295

Subject(s)

Apoptosis/drug effects; Blood Platelets/metabolism; Carrier Proteins/pharmacology; Peptides/pharmacology; Platelet Activation/drug effects; Pyrimidines/pharmacology; Sulfones/pharmacology; Animals; Blood Platelets/cytology; Calcium/metabolism; Caspase 3/metabolism; Female; Flow Cytometry; Male; Mice; ORAI1 Protein/metabolism; P-Selectin/metabolism; Phosphatidylserines/pharmacology; Platelet Aggregation/drug effects; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism

Key words

CRP; Caspase; Cell volume; Cytosolic Ca2+ concentration; Degranulation; Integrin; Orai1; Oxidative stress; Phosphatidylserine translocation; Platelet activation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Pyrimidines / Sulfones / Blood Platelets / Carrier Proteins / Platelet Activation / Apoptosis Limits: Animals Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2018 Type: Article Affiliation country: Germany

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