Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.

Lee, Sujin; Cil, Onur; Diez-Cecilia, Elena; Anderson, Marc O; Verkman, Alan S

Lee, Sujin; Cil, Onur; Diez-Cecilia, Elena; Anderson, Marc O; Verkman, Alan S.

Affiliation

Diez-Cecilia E; Department of Chemistry and Biochemistry , San Francisco State University , San Francisco , California 94132-1722 , United States.
Anderson MO; Department of Chemistry and Biochemistry , San Francisco State University , San Francisco , California 94132-1722 , United States.

J Med Chem ; 61(7): 3209-3217, 2018 04 12.

Article in En | MEDLINE | ID: mdl-29589443

Subject(s)

Kidney/metabolism; Membrane Transport Proteins/drug effects; Quinoxalines/chemical synthesis; Quinoxalines/pharmacology; Animals; Diuresis/drug effects; Diuretics/chemical synthesis; Diuretics/pharmacology; Dogs; Humans; Kidney/drug effects; Madin Darby Canine Kidney Cells; Male; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Osmolar Concentration; Quinoxalines/pharmacokinetics; Rats; Rats, Wistar; Structure-Activity Relationship; Urea/metabolism; Urea Transporters

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Quinoxalines / Kidney Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Type: Article

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