Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression.

Banas, Tomasz; Pitynski, Kazimierz; Okon, Krzysztof; Winiarska, Aleksandra

Banas, Tomasz; Pitynski, Kazimierz; Okon, Krzysztof; Winiarska, Aleksandra.

Affiliation

Banas T; Department of Gynecology and Oncology, Jagiellonian University, 21 Kopernika Street, 30-501, Krakow, Poland. tbanas@mp.pl.
Pitynski K; Department of Gynecology and Oncology, Jagiellonian University, 21 Kopernika Street, 30-501, Krakow, Poland.
Okon K; Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.
Winiarska A; Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.

BMC Cancer ; 18(1): 418, 2018 04 13.

Article in En | MEDLINE | ID: mdl-29653556

Subject(s)

Apoptosis Regulatory Proteins/genetics; Deoxyribonucleases/genetics; Endometrial Neoplasms/genetics; Endometrial Neoplasms/mortality; Poly-ADP-Ribose Binding Proteins/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; Apoptosis Regulatory Proteins/metabolism; Biomarkers, Tumor; Deoxyribonucleases/metabolism; Endometrial Neoplasms/pathology; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymph Nodes/pathology; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Poly-ADP-Ribose Binding Proteins/metabolism; Proportional Hazards Models; Proto-Oncogene Proteins c-bcl-2/metabolism; Reproducibility of Results

Key words

B-cell lymphoma 2 (BCL2); DNA fragmentation factor 40 (DFF40); DNA fragmentation factor 45 (DFF45); Disease-free survival (DFS); Endometrial cancers (ECs); Overall survival (OS)

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endometrial Neoplasms / Proto-Oncogene Proteins c-bcl-2 / Deoxyribonucleases / Apoptosis Regulatory Proteins / Poly-ADP-Ribose Binding Proteins Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2018 Type: Article Affiliation country: Poland

Fulltext

XML

PubMed Links

Search on Google