Downstream processing of a ternary amorphous solid dispersion: The impacts of spray drying and hot melt extrusion on powder flow, compression and dissolution.

Davis, Mark T; Potter, Catherine B; Walker, Gavin M

Davis, Mark T; Potter, Catherine B; Walker, Gavin M.

Affiliation

Davis MT; The Synthesis and Solid State Pharmaceutical Centre (SSPC), Bernal Institute, The University of Limerick, Ireland. Electronic address: mark.davis@ul.ie.
Potter CB; The Synthesis and Solid State Pharmaceutical Centre (SSPC), Bernal Institute, The University of Limerick, Ireland.
Walker GM; The Synthesis and Solid State Pharmaceutical Centre (SSPC), Bernal Institute, The University of Limerick, Ireland.

Int J Pharm ; 544(1): 242-253, 2018 Jun 10.

Article in En | MEDLINE | ID: mdl-29689366

Subject(s)

Antifungal Agents/chemistry; Drug Compounding/methods; Itraconazole/chemistry; Desiccation/methods; Drug Liberation; Excipients/chemistry; Hot Temperature; Microscopy, Electron, Scanning; Particle Size; Powders; Rheology; Tablets

Key words

Amorphous; Compression; Dissolution; Flow; Itraconazole; Tabletting

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Itraconazole / Drug Compounding / Antifungal Agents Language: En Journal: Int J Pharm Year: 2018 Type: Article

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