Improving the <i>In Vivo</i> Efficacy of an Anti-Tac (CD25) Immunotoxin by <i>Pseudomonas</i> Exotoxin A Domain II Engineering.

Kaplan, Gilad; Mazor, Ronit; Lee, Fred; Jang, Youjin; Leshem, Yasmin; Pastan, Ira

Improving the In Vivo Efficacy of an Anti-Tac (CD25) Immunotoxin by Pseudomonas Exotoxin A Domain II Engineering.

Kaplan, Gilad; Mazor, Ronit; Lee, Fred; Jang, Youjin; Leshem, Yasmin; Pastan, Ira.

Affiliation

Kaplan G; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Mazor R; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Lee F; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Jang Y; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Leshem Y; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.
Pastan I; Laboratory of Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland. pastani@mail.nih.gov.

Mol Cancer Ther ; 17(7): 1486-1493, 2018 07.

Article in En | MEDLINE | ID: mdl-29695631

Subject(s)

ADP Ribose Transferases/administration & dosage; Antibodies, Monoclonal/administration & dosage; Bacterial Toxins/administration & dosage; Exotoxins/administration & dosage; Hematologic Neoplasms/drug therapy; Protein Engineering; Virulence Factors/administration & dosage; ADP Ribose Transferases/genetics; ADP Ribose Transferases/immunology; Animals; Antibodies, Monoclonal/genetics; Antibodies, Monoclonal/immunology; Bacterial Toxins/genetics; Bacterial Toxins/immunology; Cell Line, Tumor; Cell Proliferation/drug effects; Cytotoxicity, Immunologic/genetics; Exotoxins/genetics; Exotoxins/immunology; Hematologic Neoplasms/genetics; Hematologic Neoplasms/immunology; Humans; Interleukin-2 Receptor alpha Subunit/antagonists & inhibitors; Interleukin-2 Receptor alpha Subunit/immunology; Mesothelin; Mice; Point Mutation/genetics; Protein Domains/genetics; Protein Domains/immunology; Sialic Acid Binding Ig-like Lectin 2/antagonists & inhibitors; Sialic Acid Binding Ig-like Lectin 2/immunology; T-Lymphocytes/drug effects; T-Lymphocytes/immunology; Virulence Factors/genetics; Virulence Factors/immunology; Xenograft Model Antitumor Assays; Pseudomonas aeruginosa Exotoxin A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Toxins / Protein Engineering / ADP Ribose Transferases / Hematologic Neoplasms / Virulence Factors / Exotoxins / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2018 Type: Article

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